Sodium Hydroxide → HCID 59643371, compound

HRID 2251525Notes

Reaction equation

HRID 2251525 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=2)[CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][C:14]([O:15][C:16]([CH3:23])([CH3:22])[C:17]([O:19]CC)=[O:18])=[CH:13][CH:12]=2)=[N:6][CH:7]=1.[OH-].[Na+]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:26][C:27]2[CH:28]=[CH:29][C:30]([C:33]([F:36])([F:34])[F:35])=[CH:31][CH:32]=2)[CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][C:14]([O:15][C:16]([CH3:22])([CH3:23])[C:17]([OH:19])=[O:18])=[CH:13][CH:12]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 59643333HCID 59643333, compound

Product 1

HCID 59643371HCID 59643371, compoundYield 52%

Procedure

Hydrolysis of ethyl 2-[4-(2-{(5-bromopyridin-2-yl)[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate with NaOH as per general procedure H provided after chromatography and crystallization from dichloromethane-hexane, the title compound as a white solid (56 mg; 52% yield).

Workup

  1. customprovided
  2. customafter chromatography and crystallization from dichloromethane-hexane

Sources & evidence

ORD record
ord-2e68b701ba11426fbf68ad01f6938a64
Source dataset
uspto-grants-2008_01
Patent number
US07319104B2

Reaction notes

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