Tributylvinyltin → HCID 59643296, compound

HRID 2251528Notes

Reaction equation

Br[C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([O:33][C:34]([F:37])([F:36])[F:35])=[CH:29][CH:28]=2)[CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][C:14]([O:15][C:16]([CH3:23])([CH3:22])[C:17]([O:19]CC)=[O:18])=[CH:13][CH:12]=2)=[N:6][CH:7]=1.[CH:38]([Sn](CCCC)(CCCC)CCCC)=[CH2:39]>>[CH2:38]([C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([O:33][C:34]([F:37])([F:35])[F:36])=[CH:29][CH:28]=2)[CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][C:14]([O:15][C:16]([CH3:22])([CH3:23])[C:17]([OH:19])=[O:18])=[CH:13][CH:12]=2)=[N:6][CH:7]=1)[CH3:39]

Participants

Reactant 2

HCID 81998Tributylvinyltin

HCID 59643326HCID 59643326, compound

Product 1

HCID 59643296HCID 59643296, compound

Procedure

Similarly prepared from ethyl 2-[4-(2-{(5-bromopyridin-2-yl)[4-(trifluoromethoxy)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate and vinyltributyltin. 1H NMR (CDCl3) δ 8.02 (d, 1H, J=2.0), 7.32 (dd, 1H, J=8.8; 2.0), 7.12 (d, 2H, J=8.6), 7.07 (d, 2H, J=8.5), 7.0 (d, 2H, J=8.4), 6.82 (d, 2H, J=8.4), 6.42 (d, 1H, J=8.8), 4.50 (s, 2H), 3.67 (t, 2H, J=7.4), 2.80 (t, 2H, J=7.4), 2.49 (q, 2H, J=7.6), 1.55 (s, 6H), 1.19 (t, 3H, J=7.6). MS: m/z 503 (M+1).

Sources & evidence

ORD record: ord-6f092f45c2114b308c7eea8895c10ca9
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07319104B2

Reaction notes

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