Lithium Hydroxide → HCID 59643275, compound

HRID 2251533Notes

Reaction equation

[C:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]([CH2:28][C:29]2[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][CH:30]=2)[CH2:11][CH2:12][C:13]2[CH:27]=[CH:26][C:16]([O:17][C:18]([CH3:25])([CH3:24])[C:19]([O:21]CC)=[O:20])=[CH:15][CH:14]=2)=[N:8][CH:9]=1)(=[O:3])[CH3:2].[Li+].[OH-]>>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]([CH2:28][C:29]2[CH:30]=[CH:31][C:32]([C:35]([F:37])([F:36])[F:38])=[CH:33][CH:34]=2)[CH2:11][CH2:12][C:13]2[CH:27]=[CH:26][C:16]([O:17][C:18]([CH3:25])([CH3:24])[C:19]([OH:21])=[O:20])=[CH:15][CH:14]=2)=[N:8][CH:9]=1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 59643195HCID 59643195, compound

Product 1

HCID 59643275HCID 59643275, compound

Procedure

Hydrolysis of ethyl 2-[4-(2-{(5-acetylpyridin-2-yl)[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate with LiOH as per general procedure H afforded after a standard aqueous workup the title compound.

Sources & evidence

ORD record: ord-691f54b82d7643918a0d185e4f8af65d
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07319104B2

Reaction notes

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