HRID2251547

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11745

Ethyl 2-bromoisobutyrate

C6H11BrO2

结构：CC(C)c1ccc(N(CCCc2cccc(O)c2)Cc2ccc(OC(F)(F)F)cc2)nc1

HCID59643168

未命名化合物

PRODUCTS

生成物

结构：CC(C)c1ccc(N(CCCc2cccc(OC(C)(C)C(=O)O)c2)Cc2ccc(OC(F)(F)F)cc2)nc1

HCID59643349

未命名化合物

PROCEDURE

实验过程

Similarly prepared by alkylation of 3-(3-{(5-isopropylpyridin-2-yl)[4-(trifluoromethoxy)benzyl]amino}propyl)phenol with ethyl-2-bromo-isobutyrate followed by standard base-mediated hydrolysis.

WORKUP

后处理

customfollowed by standard base-mediated hydrolysis

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ff168f1c7afa4e61afa0bb6a62fb5b6b
来源数据集: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07319104B2
来源说明: uspto-grants-2008_01

反应 SMILES

[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][C:29]([F:32])([F:31])[F:30])=[CH:24][CH:23]=2)[CH2:11][CH2:12][CH2:13][C:14]2[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=2)=[N:8][CH:9]=1)([CH3:3])[CH3:2].C([O:35][C:36](=[O:41])[C:37](Br)([CH3:39])[CH3:38])C>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]([CH2:21][C:22]2[CH:23]=[CH:24][C:25]([O:28][C:29]([F:32])([F:30])[F:31])=[CH:26][CH:27]=2)[CH2:11][CH2:12][CH2:13][C:14]2[CH:15]=[C:16]([CH:17]=[CH:18][CH:19]=2)[O:20][C:37]([CH3:39])([CH3:38])[C:36]([OH:41])=[O:35])=[N:8][CH:9]=1)([CH3:3])[CH3:2]