Trifluoroacetic acid → HCID 59643137, compound

HRID 2251577Notes

Reaction equation

[NH2:1]/[C:2](/[N:5]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=1)[CH2:6][CH2:7][C:8]1[CH:24]=[CH:23][C:11]([O:12][C:13]([CH3:22])([CH3:21])[C:14]([O:16]C(C)(C)C)=[O:15])=[CH:10][CH:9]=1)=[N:3]\[OH:4].[F:36][C:37]([F:48])([F:47])[C:38]1[CH:46]=[CH:45][C:41]([C:42](Cl)=O)=[CH:40][CH:39]=1.C(O)(C(F)(F)F)=O>>[CH3:21][C:13]([O:12][C:11]1[CH:10]=[CH:9][C:8]([CH2:7][CH2:6][N:5]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:33])[F:34])=[CH:28][CH:27]=2)[C:2]2[N:1]=[C:42]([C:41]3[CH:40]=[CH:39][C:38]([C:37]([F:36])([F:47])[F:48])=[CH:46][CH:45]=3)[O:4][N:3]=2)=[CH:24][CH:23]=1)([CH3:22])[C:14]([OH:16])=[O:15]

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 676074-(Trifluoromethyl)benzoyl chloride

HCID 59643363HCID 59643363, compound

Product 1

HCID 59643137HCID 59643137, compound

Procedure

Similarly prepared by condensation of tert-butyl 2-[4-(2-{[(E)-amino(hydroxyimino)methyl][4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate with 4-trifluoromethylbenzoyl chloride, followed by standard TFA hydrolysis.

Sources & evidence

ORD record: ord-73ef162fb97644528a17d79a43565573
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07319104B2

Reaction notes

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