HRID2251585

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68303

Ethanone, 2-bromo-1-(4-chlorophenyl)-

C8H6BrClO

结构：CCOC(=O)C(C)(C)Oc1ccc(CCN(Cc2ccc(C(F)(F)F)cc2)C(N)=S)cc1

HCID59643246

未命名化合物

PRODUCTS

生成物

结构：CC(C)(Oc1ccc(CCN(Cc2ccc(C(F)(F)F)cc2)c2nc(-c3ccc(Cl)cc3)cs2)cc1)C(=O)O

HCID59643166

未命名化合物

PROCEDURE

实验过程

Similarly prepared from ethyl 2-[4-(2-{(aminocarbonothioyl)[4-(trifluoromethyl)benzyl]amino}ethyl)phenoxy]-2-methylpropanoate and 4-chlorophenacyl bromide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-25a33ff172504f03ac00eb3d60472e22
来源数据集: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07319104B2
来源说明: uspto-grants-2008_01

反应 SMILES

[NH2:1][C:2]([N:4]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=1)[CH2:5][CH2:6][C:7]1[CH:21]=[CH:20][C:10]([O:11][C:12]([CH3:19])([CH3:18])[C:13]([O:15]CC)=[O:14])=[CH:9][CH:8]=1)=[S:3].[Cl:33][C:34]1[CH:43]=[CH:42][C:37]([C:38](=O)[CH2:39]Br)=[CH:36][CH:35]=1>>[Cl:33][C:34]1[CH:43]=[CH:42][C:37]([C:38]2[N:1]=[C:2]([N:4]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)[CH2:5][CH2:6][C:7]3[CH:8]=[CH:9][C:10]([O:11][C:12]([CH3:19])([CH3:18])[C:13]([OH:15])=[O:14])=[CH:20][CH:21]=3)[S:3][CH:39]=2)=[CH:36][CH:35]=1