Methyl 2,3-bis-benzyloxy-5-trifluoromethyl-benzoate → Methyl 2,3-dihydroxy-5-trifluoromethyl-benzoate

HRID 2251609Notes

Reaction equation

HRID 2251609 reaction equation
C([O:8][C:9]1[C:18]([O:19]CC2C=CC=CC=2)=[CH:17][C:16]([C:27]([F:30])([F:29])[F:28])=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12])C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[C:18]([OH:19])=[CH:17][C:16]([C:27]([F:28])([F:29])[F:30])=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12]

Participants

4

Reactant 1

HCID 59642996Methyl 2,3-bis-benzyloxy-5-trifluoromethyl-benzoate

Product 1

HCID 59643027Methyl 2,3-dihydroxy-5-trifluoromethyl-benzoate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of methyl 2,3-bis-benzyloxy-5-trifluoromethyl-benzoate (280 mg, 0.67 mmol) in 10 mL MeOH, Pd/C (10%, 30 mg) was added and the mixture was stirred 16 h under a H2 atmosphere. The reaction mixture was then filtered through Celite and evaporated in vacuo to yield the title compound as a greyish solid.

Workup

  1. filtrationThe reaction mixture was then filtered through Celite
  2. customevaporated in vacuo

Sources & evidence

ORD record
ord-a946540104ad47819fefbeec3382bcac
Source dataset
uspto-grants-2008_01
Patent number
US07319101B2

Reaction notes

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