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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2251609Generated: October 27, 2026

Methyl 2,3-bis-benzyloxy-5-trifluoromethyl-benzoate → Methyl 2,3-dihydroxy-5-trifluoromethyl-benzoate

https://huagongshe.com/reaction/2251609

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2,3-bis-benzyloxy-5-trifluoromethyl-benzoateHCID 59642996—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
ProductMethyl 2,3-dihydroxy-5-trifluoromethyl-benzoateHCID 59643027—

Reaction Steps

To a solution of methyl 2,3-bis-benzyloxy-5-trifluoromethyl-benzoate (280 mg, 0.67 mmol) in 10 mL MeOH, Pd/C (10%, 30 mg) was added and the mixture was stirred 16 h under a H2 atmosphere. The reaction mixture was then filtered through Celite and evaporated in vacuo to yield the title compound as a greyish solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07319101B2
Source datasetuspto-grants-2008_01
ORD IDord-a946540104ad47819fefbeec3382bcac
Source noteuspto-grants-2008_01