4,4'-Dimethoxybenzophenone → HCID 59643010, compound

HRID 2251617Notes

Reaction equation

HRID 2251617 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:4]=1.C(Cl)(=O)C(Cl)=O.O[C:26]1[C:35]([OH:36])=[CH:34][C:33]([S:37]([C:40]2[CH:45]=[CH:44][C:43]([CH3:46])=[CH:42][CH:41]=2)(=[O:39])=[O:38])=[CH:32][C:27]=1[C:28]([O:30][CH3:31])=[O:29]>>[CH3:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([C:7]2([C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:18][CH:17]=3)[O:36][C:35]3[CH:34]=[C:33]([S:37]([C:40]4[CH:45]=[CH:44][C:43]([CH3:46])=[CH:42][CH:41]=4)(=[O:39])=[O:38])[CH:32]=[C:27]([C:28]([O:30][CH3:31])=[O:29])[C:26]=3[O:8]2)=[CH:10][CH:11]=1

Participants

4

Reactant 3

HCID 70324,4'-DimethoxybenzophenoneHCID 65578Oxalyl chlorideHCID 59642987HCID 59642987, compound

Product 1

HCID 59643010HCID 59643010, compound

Procedure

4,4′-Dimethoxybenzophenone (225 mg, 0.93 mmol, 1.5 eq.), oxalyl chloride (944 mg, 7.44 mmol, 8 eq.) and methyl 2,3-dihydroxy-5-(toluene-4-sulfonyl)-benzoate (200 mg, 0.62 mmol, 1 eq.) were reacted according to GP2.2. The crude product was purified using flash chromatography (silica gel, hexane/EtOAc 20:1→9:1) to yield the title compound as a colorless solid.

Workup

  1. customThe crude product was purified

Sources & evidence

ORD record
ord-3c975ab92c1a4faaaea4daca4be06aa1
Source dataset
uspto-grants-2008_01
Patent number
US07319101B2

Reaction notes

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