反应详情

To a solution of 2,3-dihydroxy-5-(4-methyl-benzoyl)-benzoic acid (214 mg, 0.79 mmol) in 10 mL dry THF cooled to 0° C., N-hydroxysuccinimide (136 mg, 1.18 mmol, 1.5 eq.) and N-cyclohexylcarbodiimide, N′-methyl polystyrene HL (Novabiochem) (1.9 eq./g, 832 mg, 2 eq.) were added and the solution was stirred 14 h while the cooling bath slowly warmed up to r.t. The solution was filtered and the filtrate was evaporated under reduced pressure. The crude product was recrystallised from H2O to yield the desired product as a brownish solid.

1. filtrationThe solution was filtered
2. customthe filtrate was evaporated under reduced pressure
3. customThe crude product was recrystallised from H2O