Methylamine → HCID 23329128, compound

HRID 225164Notes

Reaction equation

HRID 225164 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:15])[CH2:9][CH2:10][C:11](OC)=[O:12])=[CH:4][C:3]=1[S:16](=[O:20])(=[O:19])[NH:17][CH3:18].[CH3:21][NH2:22]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:15])[N:22]([CH3:21])[C:11](=[O:12])[CH2:10][CH2:9]2)=[CH:4][C:3]=1[S:16](=[O:20])(=[O:19])[NH:17][CH3:18]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 23329105HCID 23329105, compound

Product 1

HCID 23329128HCID 23329128, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7.9 of methyl 4-(4-chloro-3-methylsulfamoylphenyl)-4-oxobutanoate are reacted with 6.9 g of methylamine in 100 ml of methanol and the mixture is worked up analogously to the instructions indicated in Example 2(b). 5-(4-Chloro-3-methylsulfamoylphenyl)-5-hydroxy-1-methyl-2-oxopyrrolidine of melting point 147°-150° C. is obtained.

Sources & evidence

ORD record
ord-85446484a4cd4948bc47ebf768046a01
Source dataset
uspto-grants-1980_11
Patent number
US04235918

Reaction notes

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