3,5-Dimethylisoxazole-4-boronic acid → 5-(3,5-Dimethylisoxazol-4-yl)-3,3-dimethylindan-1-one

HRID 2251661Notes

Reaction equation

HRID 2251661 reaction equation
[CH3:1][C:2]1([CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8](OS(C(F)(F)F)(=O)=O)[CH:9]=2)[C:4](=[O:19])[CH2:3]1.[CH3:21][C:22]1[C:26](B(O)O)=[C:25]([CH3:30])[O:24][N:23]=1>>[CH3:21][C:22]1[C:26]([C:8]2[CH:9]=[C:10]3[C:5](=[CH:6][CH:7]=2)[C:4](=[O:19])[CH2:3][C:2]3([CH3:20])[CH3:1])=[C:25]([CH3:30])[O:24][N:23]=1

Participants

3

Reactant 2

HCID 27343463,5-Dimethylisoxazole-4-boronic acidHCID 57618520Trifluoromethanesulfonic acid 3,3-dimethyl-1-oxo-indan-5-yl ester

Product 1

HCID 690385615-(3,5-Dimethylisoxazol-4-yl)-3,3-dimethylindan-1-one

Procedure

The title compound was prepared from trifluoro-methanesulfonic acid 3,3-dimethyl-1-oxo-indan-5-yl ester and 3,5-dimethylisoxazole-4-boronic acid according to the coupling procedure described in example 21. MS m/z 256; HRMS: calcd for C16H17NO2+H+, 256.13321; found (ESI, [M+H]+), 256.1343.

Sources & evidence

ORD record
ord-41aa709aaed0408a98e46d1eba55761d
Source dataset
uspto-grants-2008_01
Patent number
US07319152B2

Reaction notes

Loading…