3,5-Dichlorophenylboronic acid → 5-(3,5-Dichlorophenyl)-3,3-dimethylindan-1-one

HRID 2251670Notes

Reaction equation

HRID 2251670 reaction equation
[CH3:1][C:2]1([CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8](OS(C(F)(F)F)(=O)=O)[CH:9]=2)[C:4](=[O:19])[CH2:3]1.[Cl:21][C:22]1[CH:23]=[C:24](B(O)O)[CH:25]=[C:26]([Cl:28])[CH:27]=1>>[Cl:21][C:22]1[CH:23]=[C:24]([C:8]2[CH:9]=[C:10]3[C:5](=[CH:6][CH:7]=2)[C:4](=[O:19])[CH2:3][C:2]3([CH3:20])[CH3:1])[CH:25]=[C:26]([Cl:28])[CH:27]=1

Participants

3

Reactant 2

HCID 27343313,5-Dichlorophenylboronic acidHCID 57618520Trifluoromethanesulfonic acid 3,3-dimethyl-1-oxo-indan-5-yl ester

Product 1

HCID 690363505-(3,5-Dichlorophenyl)-3,3-dimethylindan-1-one

Procedure

The title compound was prepared from trifluoro-methanesulfonic acid 3,3-dimethyl-1-oxo-indan-5-yl ester and 3,5-dichlorophenyl boronic acid according to the procedure described in example 21. MS (ES) m/z 305.1; HRMS: calcd for C17H14Cl2O+H+, 305.04944; found (ESI, [M+H]+), 305.0509.

Sources & evidence

ORD record
ord-94ce3c6b310c41c9b8623644cf78365f
Source dataset
uspto-grants-2008_01
Patent number
US07319152B2

Reaction notes

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