4-(Trifluoromethyl)phenylboronic acid → 3,3-Dimethyl-5-[4-(trifluoromethyl)phenyl]indan-1-one

HRID 2251679Notes

Reaction equation

HRID 2251679 reaction equation
[CH3:1][C:2]1([CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8](OS(C(F)(F)F)(=O)=O)[CH:9]=2)[C:4](=[O:19])[CH2:3]1.[F:21][C:22]([F:33])([F:32])[C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1>>[CH3:20][C:2]1([CH3:1])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:26]3[CH:27]=[CH:28][C:23]([C:22]([F:33])([F:32])[F:21])=[CH:24][CH:25]=3)[CH:9]=2)[C:4](=[O:19])[CH2:3]1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 57618520Trifluoromethanesulfonic acid 3,3-dimethyl-1-oxo-indan-5-yl ester

Product 1

HCID 690391173,3-Dimethyl-5-[4-(trifluoromethyl)phenyl]indan-1-one

Procedure

The title compound was prepared from trifluoro-methanesulfonic acid 3,3-dimethyl-1-oxo-indan-5-yl ester and 4-(trifluoromethyl)phenyl boronic acid according to the procedure described in example 21. MS m/z 305; HRMS: calcd for C18H15F3O+H+, 305.11478; found (ESI, [M+H]+), 305.1145.

Sources & evidence

ORD record
ord-e9d1cf3b1e8e4dbb9d3550aaf48aaff3
Source dataset
uspto-grants-2008_01
Patent number
US07319152B2

Reaction notes

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