(3-Cyano-5-fluorophenyl)boronic acid → 3-(3,3-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)-5-fluorobenzonitrile

HRID 2251684Notes

Reaction equation

HRID 2251684 reaction equation
[CH3:1][C:2]1([CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8](OS(C(F)(F)F)(=O)=O)[CH:9]=2)[C:4](=[O:19])[CH2:3]1.[C:21]([C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[C:27]([F:29])[CH:28]=1)#[N:22]>>[CH3:20][C:2]1([CH3:1])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:25]3[CH:24]=[C:23]([CH:28]=[C:27]([F:29])[CH:26]=3)[C:21]#[N:22])[CH:9]=2)[C:4](=[O:19])[CH2:3]1

Participants

3

Reactant 2

HCID 23435605(3-Cyano-5-fluorophenyl)boronic acidHCID 57618520Trifluoromethanesulfonic acid 3,3-dimethyl-1-oxo-indan-5-yl ester

Product 1

HCID 690379493-(3,3-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)-5-fluorobenzonitrile

Procedure

The title compound was prepared from trifluoro-methanesulfonic acid 3,3-dimethyl-1-oxo-indan-5-yl ester and 3-cyano-5-fluorophenyl boronic acid according to the procedure described in example 21. MS (ES) m/z 280.1; HRMS: calcd for C18H14FNO+H+, 280.11322; found (ESI, [M+H]+), 280.1129.

Sources & evidence

ORD record
ord-c3f628d4768847b698ce909c51efd8ef
Source dataset
uspto-grants-2008_01
Patent number
US07319152B2

Reaction notes

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