反应详情

温度

2.5 °C

A mixture of 5 g (0.026 mole) of 3-chlorobiphenyl, 50 ml of methylene chloride, 6.95 g (0.034 mole) of bromoacetyl bromide is cooled to 0-5° C. and 4 g (0.030 mole) of aluminium trichloride are added thereto. Stirring is effected for 1 hour at 5° C. and then 4 hours at room temperature. The mixture is poured into a water/ice mixture, extracted with methylene chloride, the organic phase is washed with a 1N HCl solution, drying is effected over sodium sulphate and the residu is evaporated under reduced pressure. 4.5 g of the title compound are obtained. M.p. 63-65° C.

1. custom4 hours
2. customat room temperature
3. extractionextracted with methylene chloride
4. washthe organic phase is washed with a 1N HCl solution
5. customdrying
6. customthe residu is evaporated under reduced pressure