Methyl morpholine oxide → 6-Quinolinecarbaldehyde

Participants

Reaction Steps

To a stirred solution of quinolin-6-yl-methanol (1.14 g, 7.16 mmol) in CH2Cl2 (100 mL) at 0° C. were added N-methylmorpholine N-oxide (1.25 g, 10.7 mmol), 4 Å molecular sieves (500 mg) and TPAP (60 mg). The mixture was stirred at RT until the starting material was consumed, then filtered through a Celite® pad. Solvent was evaporated to give the aldehyde.

Provenance & Evidence