反应详情

2-Bromo-6-methyl-benzoic acid methyl ester (2.18 g), NBS (4.89 g), and AIBN (0.486 g) were taken into CCl4 (15 mL) and heated at reflux for 8 h. After cooling to RT, the solid was removed by filtration, and the filtrate was concentrated to give an orange oil as crude material. Purification by chromatography (silica gel, 100 g, 5-15% EtOAc/hexanes) afforded 2-bromo-6-bromomethyl-benzoic acid methyl ester as colorless oil.

1. temperatureheated
2. temperatureat reflux for 8 h
3. customthe solid was removed by filtration
4. concentrationthe filtrate was concentrated
5. customto give an orange oil as crude material
6. customPurification by chromatography (silica gel, 100 g, 5-15% EtOAc/hexanes)