Ether hydrochloride → (R)-7-Chloro-5,11-dihydro-5-[1-(3,4-methylenedioxyphenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine hydrochloride

HRID 2251880Notes

Reaction equation

HRID 2251880 reaction equation
Cl.C(OCC)C.[Cl:7][C:8]1[CH:39]=[CH:38][C:11]2[O:12][CH2:13][C:14]3[CH:37]=[CH:36][CH:35]=[CH:34][C:15]=3[N:16]([CH2:17][C@H:18]3[CH2:22][CH2:21][CH2:20][N:19]3[CH2:23][CH2:24][C:25]3[CH:30]=[CH:29][C:28]4[O:31][CH2:32][O:33][C:27]=4[CH:26]=3)[C:10]=2[CH:9]=1>ClCCl>[ClH:7].[Cl:7][C:8]1[CH:39]=[CH:38][C:11]2[O:12][CH2:13][C:14]3[CH:37]=[CH:36][CH:35]=[CH:34][C:15]=3[N:16]([CH2:17][C@H:18]3[CH2:22][CH2:21][CH2:20][N:19]3[CH2:23][CH2:24][C:25]3[CH:30]=[CH:29][C:28]4[O:31][CH2:32][O:33][C:27]=4[CH:26]=3)[C:10]=2[CH:9]=1

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 59643983(R)-7-chloro-5,11-dihydro-5-[1-(3,4-methylenedioxyphenethyl)pyrrolidin-2-ylmethyl]-dibenzo[b,e][1,4]oxazepine

Product 1

HCID 69200328(R)-7-Chloro-5,11-dihydro-5-[1-(3,4-methylenedioxyphenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.0 ml of 2 M hydrogen chloride/diethyl ether was added to a solution of (R)-7-chloro-5,11-dihydro-5-[1-(3,4-methylenedioxyphenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (0.63 g) in dichloromethane (5 ml), and they were stirred together for 2 hours. The solvent was evaporated under reduced pressure. The obtained residue was stirred in hexane to obtain the title compound in the form of a light brown solid (348 mg, 89%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. stirringThe obtained residue was stirred in hexane

Sources & evidence

ORD record
ord-9a61207315c8487198a8c9dce57e4f4c
Source dataset
uspto-grants-2008_01
Patent number
US07320973B2

Reaction notes

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