1,4-Dioxane hydrochloride → HCID 69199455, compound

HRID 2251883Notes

Reaction equation

HRID 2251883 reaction equation
[ClH:1].O1CCOCC1.[F:8][C:9]1[C:19]2[CH2:18][O:17][C:16]3[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=3[N:14]([CH2:24][C@H:25]3[CH2:29][CH2:28][CH2:27][N:26]3[CH2:30][CH2:31][C:32]3[CH:37]=[CH:36][C:35]([N:38]([CH3:40])[CH3:39])=[CH:34][CH:33]=3)[C:13]=2[CH:12]=[CH:11][CH:10]=1>ClCCl>[ClH:1].[ClH:1].[F:8][C:9]1[C:19]2[CH2:18][O:17][C:16]3[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=3[N:14]([CH2:24][C@H:25]3[CH2:29][CH2:28][CH2:27][N:26]3[CH2:30][CH2:31][C:32]3[CH:33]=[CH:34][C:35]([N:38]([CH3:39])[CH3:40])=[CH:36][CH:37]=3)[C:13]=2[CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59643996HCID 59643996, compound

Product 1

HCID 69199455HCID 69199455, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.5 ml of 4 M hydrogen chloride/dioxane was added to a solution of (R)-1-fluoro-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine in dichloromethane (5 ml), and they were stirred together for 30 minutes. The solvent was evaporated under reduced pressure. The obtained residue was solidified with a mixed solvent of hexane and ethyl acetate. The solid thus precipitated was taken by the filtration to obtain the title compound in the form of a brown solid (170 mg, 64%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe solid thus precipitated
  3. filtrationwas taken by the filtration

Sources & evidence

ORD record
ord-d4f964c27abc4d1e86808ed633d11073
Source dataset
uspto-grants-2008_01
Patent number
US07320973B2

Reaction notes

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