1,4-Dioxane hydrochloride → HCID 69199455, compound

Participants

Reaction Steps

0.5 ml of 4 M hydrogen chloride/dioxane was added to a solution of (R)-1-fluoro-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine in dichloromethane (5 ml), and they were stirred together for 30 minutes. The solvent was evaporated under reduced pressure. The obtained residue was solidified with a mixed solvent of hexane and ethyl acetate. The solid thus precipitated was taken by the filtration to obtain the title compound in the form of a brown solid (170 mg, 64%).

Provenance & Evidence