HCID 9828562, compound → HCID 9828561, compound

Participants

Reaction Steps

(R)-3-Chloro-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (306 mg, 0.662 mmol) was dissolved in 6.0 ml of a mixed solvent of ethyl acetate and ethanol (2:1). 2 M hydrogen chloride/ether (0.73 ml, 1.46 mmol) was added to the obtained solution. 2.0 ml of ethyl acetate was added to the mixture and they were stirred at room temperature. After leaving the reaction mixture to stand at room temperature for 2 days followed by the filtration and drying, the title compound was obtained in the form of white crystals (96%).

Provenance & Evidence