HCID 9828562, compound → HCID 9828561, compound

HRID 2251884Notes

Reaction equation

HRID 2251884 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][O:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[N:7]([CH2:16][C@H:17]3[CH2:21][CH2:20][CH2:19][N:18]3[CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([N:30]([CH3:32])[CH3:31])=[CH:26][CH:25]=3)[C:6]=2[CH:33]=1.[ClH:34].CCOCC>C(OCC)(=O)C.C(O)C>[ClH:1].[ClH:34].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][O:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[N:7]([CH2:16][C@H:17]3[CH2:21][CH2:20][CH2:19][N:18]3[CH2:22][CH2:23][C:24]3[CH:25]=[CH:26][C:27]([N:30]([CH3:32])[CH3:31])=[CH:28][CH:29]=3)[C:6]=2[CH:33]=1

Participants

5

Reactant 2

HCID 9828562HCID 9828562, compoundHCID 10953452Ether hydrochloride

Product 1

HCID 9828561HCID 9828561, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent2×

Procedure

(R)-3-Chloro-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (306 mg, 0.662 mmol) was dissolved in 6.0 ml of a mixed solvent of ethyl acetate and ethanol (2:1). 2 M hydrogen chloride/ether (0.73 ml, 1.46 mmol) was added to the obtained solution. 2.0 ml of ethyl acetate was added to the mixture and they were stirred at room temperature. After leaving the reaction mixture to stand at room temperature for 2 days followed by the filtration and drying, the title compound was obtained in the form of white crystals (96%).

Workup

  1. customAfter leaving the reaction mixture
  2. filtrationfollowed by the filtration
  3. customdrying

Sources & evidence

ORD record
ord-7a7f2945eefd43a2a0553b6a06aad7ca
Source dataset
uspto-grants-2008_01
Patent number
US07320973B2

Reaction notes

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