Water → HCID 17940770, compound

HRID 2251933Notes

Reaction equation

HRID 2251933 reaction equation
O[C:2]([C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1)([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][Br:10].C1(C)C(S(O)(=O)=O)=CC=CC=1.O>C1(C)C=CC=CC=1>[F:17][C:14]1[CH:13]=[CH:12][C:11]([C:2]([C:18]2[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=2)=[CH:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][Br:10])=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 962WaterHCID 69252-Methylbenzenesulfonic acidHCID 17940780HCID 17940780, compound

Product 1

HCID 17940770HCID 17940770, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

31.9 g (80 mmol) 8-hydroxy-8,8-bis-(4-fluorophenyl)-octyl bromide dissolved in toluene are added to 0.3 g toluene sulfonic acid and the mixture is subsequently heated for an hour with water separator under reflux. After withdraw of the solvent, the residue is chromatographically purified over silica gel with petroleum ether/acetic acid ethyl ester (90/1): Yield 28.6 g (94%).

Workup

  1. temperatureunder reflux
  2. customAfter withdraw of the solvent
  3. customthe residue is chromatographically purified over silica gel with petroleum ether/acetic acid ethyl ester (90/1)

Sources & evidence

ORD record
ord-7289b384227a4280b765b12a5362cd26
Source dataset
uspto-grants-2008_01
Patent number
US07320993B1

Reaction notes

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