Water → HCID 17940770, compound

Participants

Reaction Steps

31.9 g (80 mmol) 8-hydroxy-8,8-bis-(4-fluorophenyl)-octyl bromide dissolved in toluene are added to 0.3 g toluene sulfonic acid and the mixture is subsequently heated for an hour with water separator under reflux. After withdraw of the solvent, the residue is chromatographically purified over silica gel with petroleum ether/acetic acid ethyl ester (90/1): Yield 28.6 g (94%).

Provenance & Evidence