反应详情

Dissolve [2-(2-chloro-benzoyl)-phenyl]-carbamic acid tert-butyl ester (850 mg, 2.6 mmol) in a saturated HCl in AcOH solution (10 mL, ˜3N in HCl), stir at room temperature for 3 hours. Concentrate, add CHCl3 and concentrate (3×) to remove remaining AcOH. Dissolve the residue in 20% i-PrOH/CHCl3, wash with saturated NaHCO3 solution (2×) and brine. Dry the combined organic layers over MgSO4 and concentrate to afford the title compound (495 mg, 83%): MS(IS) 232 (M+1).

1. concentrationConcentrate
2. additionadd CHCl3
3. concentrationconcentrate (3×)
4. customto remove
5. dissolutionDissolve the residue in 20% i-PrOH/CHCl3
6. washwash with saturated NaHCO3 solution (2×) and brine
7. dry with materialDry the combined organic layers over MgSO4
8. concentrationconcentrate