Hydrochloric Acid → HCID 23329521, compound

HRID 225213Notes

Reaction equation

HRID 225213 reaction equation
Br[CH2:2][CH2:3][N:4]1[CH:8]=[C:7]([C:9]([NH2:11])=[O:10])[C:6]([N+:12]([O-:14])=[O:13])=[N:5]1.C([O-])([O-])=O.[Na+].[Na+].Cl>>[N+:12]([C:6]1[C:7]([C:9]([NH2:11])=[O:10])=[CH:8][N:4]([CH:3]=[CH2:2])[N:5]=1)([O-:14])=[O:13]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 23329502HCID 23329502, compound

Product 1

HCID 23329521HCID 23329521, compound

Procedure

A suspension of 5 gm. of 1-(2-bromoethyl)-3-nitro-4-pyrazolecarboxamide in 100 ml. of 5 percent Na2CO3 solution was refluxed with stirring for 5 hours. The mixture was cooled in an ice bath and acidified to ph 2 with concentrated HCl. The product precipitated and was separated by filtration. The solids were washed with cold water and recrystallized from methanol-water to product 2 gm. of 3-nitro-1-vinyl-4-pyrazolecarboxamide, m.p. 150°-52° C.

Workup

  1. additionA suspension of 5 gm
  2. temperatureThe mixture was cooled in an ice bath
  3. customThe product precipitated
  4. customwas separated by filtration
  5. washThe solids were washed with cold water
  6. customrecrystallized from methanol-water to product 2 gm

Sources & evidence

ORD record
ord-e315e7fb04fe4863a6d28450b0de887b
Source dataset
uspto-grants-1980_11
Patent number
US04235995

Reaction notes

Loading…