Ammonium Hydroxide → 1-Methyl-3-nitro-1H-pyrazole-4-carboxamide

HRID 225215Notes

Reaction equation

HRID 225215 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7](Cl)=[O:8])[C:4]([N+:10]([O-:12])=[O:11])=[N:3]1.[NH4+:13].[OH-]>>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([NH2:13])=[O:8])[C:4]([N+:10]([O-:12])=[O:11])=[N:3]1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 233295081-Methyl-3-nitro-1H-pyrazole-4-carbonyl chloride

Product 1

HCID 211619201-Methyl-3-nitro-1H-pyrazole-4-carboxamide

Procedure

Seven gm. of 1-methyl-3-nitro-4-pyrazolecarbonyl chloride was added in portions to 50 ml. of concentrated NH4OH. The mixture was heated at reflux for 15 to 20 minutes, evaporated to dryness, and cooled. The resultant crystallized product was identified as 1-methyl-3-nitro-4-pyrazolecarboxamide, m.p. 190°-192° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 15 to 20 minutes
  3. customevaporated to dryness
  4. temperaturecooled
  5. customThe resultant crystallized product

Sources & evidence

ORD record
ord-f5b85ab65912469c99ddb36a75f8659f
Source dataset
uspto-grants-1980_11
Patent number
US04235995

Reaction notes

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