Methylamine → HCID 23329562, compound

HRID 225217Notes

Reaction equation

HRID 225217 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH:8]=[C:7]([C:9]([O:11]C)=O)[C:6]([N+:13]([O-:15])=[O:14])=[N:5]1.[CH3:16][NH2:17]>CO>[OH:1][CH2:2][CH2:3][N:4]1[CH:8]=[C:7]([C:9]([NH:17][CH3:16])=[O:11])[C:6]([N+:13]([O-:15])=[O:14])=[N:5]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 23329563HCID 23329563, compound

Product 1

HCID 23329562HCID 23329562, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Four gm. of methyl 1-(2-hydroxyethyl)-3-nitro-4-pyrazolecarboxylate was dissolved in a cold mixture of 25 ml. of absolute methanol and 25 ml. of condensed monomethylamine. The solution was allowed to stand in a stoppered container for 48 hours at room temperature. Evaporation of the volatile liquids under vacuum yielded a solid, which after decolorization and recrystallization from methanolisopropanol was proved to be 2.3 gm. of 1-(2-hydroxyethyl)-N-methyl-3-nitro-4-pyrazolecarboxamide, m.p. 138°-140° C.

Workup

  1. customEvaporation of the volatile liquids under vacuum
  2. customyielded a solid, which
  3. customafter decolorization and recrystallization from methanolisopropanol

Sources & evidence

ORD record
ord-23f8a2a78bba4c439d9801ab4832ae5d
Source dataset
uspto-grants-1980_11
Patent number
US04235995

Reaction notes

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