Acetone → HCID 58585190, compound

Participants

Reaction Steps

360 mg (0.44 mmol) of the compound from Example 3 are introduced into 2.0 ml of acetone, and 0.046 ml (0.57 mmol) of ethyl iodide and 0.18 ml (1.32 mmol) of triethylamine are successively added. The mixture is stirred at room temperature overnight before being diluted with dichloromethane, washed with saturated sodium bicarbonate solution, dried over magnesium sulfate and concentrated. The crude product is purified by filtration through a silica gel column (mobile phase: dichloromethane/methanol 95:5).

Provenance & Evidence