反应详情

360 mg (0.44 mmol) of the compound from Example 3 are introduced into 2.0 ml of acetone, and 0.046 ml (0.57 mmol) of ethyl iodide and 0.18 ml (1.32 mmol) of triethylamine are successively added. The mixture is stirred at room temperature overnight before being diluted with dichloromethane, washed with saturated sodium bicarbonate solution, dried over magnesium sulfate and concentrated. The crude product is purified by filtration through a silica gel column (mobile phase: dichloromethane/methanol 95:5).

1. additionare successively added
2. washwashed with saturated sodium bicarbonate solution
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated
5. filtrationThe crude product is purified by filtration through a silica gel column (mobile phase: dichloromethane/methanol 95:5)