Phosphorus oxychloride → HCID 59215150, compound

HRID 2252307Notes

Reaction equation

HRID 2252307 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11](O)[C:12]3[CH:13]=[CH:14][CH:15]=[N:16][C:17]=3[CH:18]=2)=[CH:5][CH:4]=1.O=P(Cl)(Cl)[Cl:22]>>[Cl:22][C:11]1[N:10]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH:18]=[C:17]2[C:12]=1[CH:13]=[CH:14][CH:15]=[N:16]2

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178488434HCID 178488434, compound

Product 1

HCID 59215150HCID 59215150, compoundYield 98.5%

Procedure

7-(4-Methoxyphenyl)-[1,6]naphthyridin-5-ol (13 g) and POCl3 (275 mL) was heated to 135° C. for 26 hours in a sealed tube. The mixture was cooled and the POCl3 was evaporated. The residue was poured onto ice and neutralized with 2M Na2CO3 and the precipitate was filtered and washed with H2O to yield 13.8 g of the title compound (98.5%), mp 126-127° C.

Workup

  1. temperatureThe mixture was cooled
  2. customthe POCl3 was evaporated
  3. additionThe residue was poured onto ice and neutralized with 2M Na2CO3
  4. filtrationthe precipitate was filtered
  5. washwashed with H2O

Sources & evidence

ORD record
ord-9b82c49e02a74a1484def5bbd41482e0
Source dataset
uspto-grants-2008_01
Patent number
US07321041B2

Reaction notes

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