HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-chloro-benzoic acid N'-(5-bromo-pyridin-2-yl)hydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chlorobenzoyl chloride | HCID 69110 | — |
| Reactant | 5-Bromo-2-hydrazinopyridine | HCID 11535699 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-chloro-benzoic acid N'-(5-bromo-pyridin-2-yl)hydrazide | HCID 69202004 | 85.5% |
Reaction Steps
To (5-bromo-pyridin-2-yl)-hydrazine (2.0 g, 10.6 mmol) and triethylamine (1.5 mL, 11.0 mmol) in 1:1 THF:CH2Cl2 (15 mL) was added 2-chlorobenzoyl chloride (1.34 mL, 10.6 mmol) and the resulting reaction stirred for 16 hours. The reaction was quenched with water (100 mL), the resulting solids filtered, and dried to give the title compound (2.96 g, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07321040B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-f14bd9ef1eda424fb69a28b9d5c11856 |
| Source note | uspto-grants-2008_01 |