Hydrazine hydrate (1:1) → HCID 17974479, compound

HRID 2252333Notes

Reaction equation

HRID 2252333 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:15][OH:16])=[CH:4][CH:3]=1.O.[NH2:18][NH2:19]>>[NH:18]([C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH2:15][OH:16])=[CH:4][CH:3]=1)[NH2:19]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 17974485HCID 17974485, compound

Product 1

HCID 17974479HCID 17974479, compound

Conditions

Temperature
120 °C

Procedure

A mixture of [2-(6-chloro-pyridin-3-yloxy)-phenyl]-methanol (235 mg, 1 mmol) and hydrazine monohydrate (5 mL) was heated at 120° C. for 4 hours. The reaction was then cooled and concentrated in vacuo to an oil. The residue was then diluted with saturated NaHCO3, and the aqueous extracted with methylene chloride. The organics were washed with brine, dried over sodium sulfate, and concentrated in vacuo to afford the above named compound.

Workup

  1. temperatureThe reaction was then cooled
  2. concentrationconcentrated in vacuo to an oil
  3. additionThe residue was then diluted with saturated NaHCO3
  4. extractionthe aqueous extracted with methylene chloride
  5. washThe organics were washed with brine
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated in vacuo
  8. customto afford the

Sources & evidence

ORD record
ord-b8786437ba6c495aa2c3b24878477938
Source dataset
uspto-grants-2008_01
Patent number
US07321040B2

Reaction notes

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