Potassium Hydroxide → HCID 17974489, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of isobutyric acid 2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-benzyl ester (130 mg, 0.37 mmol) and potassium hydroxide (103 mg, 1.84 mmol) in tetrahydrofuran (6 mL) and water (1 mL) was heated at 60° C. for 7 hours. The reaction was concentrated in vacuo to a solid. The residue was suspended in water, the solid filtered, then the material suspended in methylene chloride and filtered to give the above named compound as a tan solid (84 mg, 80%).

Provenance & Evidence