Potassium Hydroxide → HCID 17974489, compound

HRID 2252335Notes

Reaction equation

HRID 2252335 reaction equation
[CH:1]([C:4]1[N:8]2[CH:9]=[C:10]([O:13][C:14]3[CH:26]=[CH:25][CH:24]=[CH:23][C:15]=3[CH2:16][O:17]C(=O)C(C)C)[CH:11]=[CH:12][C:7]2=[N:6][N:5]=1)([CH3:3])[CH3:2].[OH-].[K+]>O1CCCC1.O>[CH:1]([C:4]1[N:8]2[CH:9]=[C:10]([O:13][C:14]3[CH:26]=[CH:25][CH:24]=[CH:23][C:15]=3[CH2:16][OH:17])[CH:11]=[CH:12][C:7]2=[N:6][N:5]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 69203992HCID 69203992, compound

Product 1

HCID 17974489HCID 17974489, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of isobutyric acid 2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-benzyl ester (130 mg, 0.37 mmol) and potassium hydroxide (103 mg, 1.84 mmol) in tetrahydrofuran (6 mL) and water (1 mL) was heated at 60° C. for 7 hours. The reaction was concentrated in vacuo to a solid. The residue was suspended in water, the solid filtered, then the material suspended in methylene chloride and filtered to give the above named compound as a tan solid (84 mg, 80%).

Workup

  1. concentrationThe reaction was concentrated in vacuo to a solid
  2. filtrationthe solid filtered
  3. filtrationfiltered
  4. customto give the

Sources & evidence

ORD record
ord-bc7dea3272f94ea998fe6162b914ef3b
Source dataset
uspto-grants-2008_01
Patent number
US07321040B2

Reaction notes

Loading…