Sodium Hydroxide → 7-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt

HRID 225244Notes

Reaction equation

HRID 225244 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([C:15]3[CH:16]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:19][CH:20]=3)=[CH:13][CH:12]=[N:11][C:10]=12)=[O:5])C.[OH-].[Na+:26]>C(O)C>[Na+:26].[F:23][C:21]([F:22])([F:24])[C:17]1[CH:18]=[CH:19][CH:20]=[C:15]([C:14]2[N:9]3[N:8]=[CH:7][C:6]([C:4]([O-:5])=[O:3])=[C:10]3[N:11]=[CH:12][CH:13]=2)[CH:16]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 111984377-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

Product 1

HCID 705907417-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3.35 g. of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester, 20 ml. of 5 N sodium hydroxide and 75 ml. of ethanol is heated on a steam bath for 4 hours. The mixture is cooled and solid is recovered by filtration giving the desired product, m.p. 322°-325° C. (dec.).

Workup

  1. additionA mixture of 3.35 g
  2. temperatureThe mixture is cooled
  3. filtrationsolid is recovered by filtration

Sources & evidence

ORD record
ord-ae12c026d83441e983ab9e4196755d52
Source dataset
uspto-grants-1980_11
Patent number
US04236005

Reaction notes

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