HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 7-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 7-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester | HCID 11198437 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt | HCID 70590741 | — |
Reaction Steps
A mixture of 3.35 g. of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester, 20 ml. of 5 N sodium hydroxide and 75 ml. of ethanol is heated on a steam bath for 4 hours. The mixture is cooled and solid is recovered by filtration giving the desired product, m.p. 322°-325° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04236005 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-ae12c026d83441e983ab9e4196755d52 |
| Source note | uspto-grants-1980_11 |