Sodium Acetate → 6-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine

HRID 225251Notes

Reaction equation

HRID 225251 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.C([O-])(=O)C.[Na+].Cl(O)(=O)(=O)=O.CN(C)[CH:19]=[C:20]([CH3:33])[C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[CH:24]=1)=O>C(O)(=O)C>[CH3:33][C:20]1[CH:19]=[N:1][C:2]2[N:3]([N:4]=[CH:5][CH:6]=2)[C:21]=1[C:23]1[CH:24]=[C:25]([C:29]([F:30])([F:31])[F:32])[CH:26]=[CH:27][CH:28]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 867367303-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone perchlorateHCID 178418806HCID 178418806, compound

Product 1

HCID 233298516-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 1.84 g. of 3-aminopyrazole, 50 ml. of glacial acetic acid, 1.80 g. of sodium acetate and 7.90 g. of 3-dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone perchlorate is refluxed for 6 hours and then evaporated. The residue is reacted as described in Example 1, giving the desired product, m.p. 168°-169° C.

Workup

  1. additionA mixture of 1.84 g
  2. customevaporated
  3. customThe residue is reacted

Sources & evidence

ORD record
ord-dcac562bf61f44338a2c6d0c2fb6b0c5
Source dataset
uspto-grants-1980_11
Patent number
US04236005

Reaction notes

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