HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Acetate → 6-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 3-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone perchlorate | HCID 86736730 | — |
| Reactant | HCID 178418806 | HCID 178418806 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-Methyl-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine | HCID 23329851 | — |
Reaction Steps
A mixture of 1.84 g. of 3-aminopyrazole, 50 ml. of glacial acetic acid, 1.80 g. of sodium acetate and 7.90 g. of 3-dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone perchlorate is refluxed for 6 hours and then evaporated. The residue is reacted as described in Example 1, giving the desired product, m.p. 168°-169° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04236005 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-dcac562bf61f44338a2c6d0c2fb6b0c5 |
| Source note | uspto-grants-1980_11 |