反应详情

A solution of 0.010 mole of 4-(α,α,α-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carboxylic acid in tetrahydrofuran is added dropwise to a 0.02 molar solution of diborane in tetrahydrofuran chilled in an ice bath. The mixture is allowed to warm to room temperature and stand overnight. The mixture is poured onto ice and extracted with methylene chloride. The methylene chloride extract is washed with water and dried (MgSO4). The solvent is removed under reduced pressure to give the product of the example.

1. temperaturechilled in an ice bath
2. additionThe mixture is poured onto ice
3. extractionextracted with methylene chloride
4. extractionThe methylene chloride extract
5. washis washed with water
6. dry with materialdried (MgSO4)
7. customThe solvent is removed under reduced pressure
8. customto give the product of the example