Sodium Hydroxide → HCID 23329830, compound

HRID 225262Notes

Reaction equation

HRID 225262 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[N:14]3[CH:15]=[N:16][CH:17]=[C:13]3[N:12]=[CH:11][CH:10]=2)[CH:4]=1.[Cl:20]N1C(=O)CCC1=O.[OH-].[Na+]>C(Cl)(Cl)Cl>[Cl:20][C:17]1[N:16]=[CH:15][N:14]2[C:9]([C:5]3[CH:4]=[C:3]([C:2]([F:18])([F:1])[F:19])[CH:8]=[CH:7][CH:6]=3)=[CH:10][CH:11]=[N:12][C:13]=12

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 31398ChlorosuccinimideHCID 23329831HCID 23329831, compound

Product 1

HCID 23329830HCID 23329830, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 0.01 mole of 4-(α,α,α-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine in chloroform is added 0.011 mole of N-chlorosuccinimide. The mixture is heated on a steam bath for one hour, cooled and poured into an ice-cold solution of 2.5 N sodium hydroxide. The organic layer is separated, dried (MgSO4) and passed through a column of hydrous magnesium silicate with chloroform as eluent. The eluent is concentrated to dryness to give the product of the example.

Workup

  1. temperatureThe mixture is heated on a steam bath for one hour
  2. temperaturecooled
  3. customThe organic layer is separated
  4. dry with materialdried (MgSO4)
  5. concentrationThe eluent is concentrated to dryness
  6. customto give the product of the example

Sources & evidence

ORD record
ord-0c1d581b58f245a195b7731368987268
Source dataset
uspto-grants-1980_11
Patent number
US04236005

Reaction notes

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