Acetic Acid → HCID 23329856, compound

HRID 225267Notes

Reaction equation

HRID 225267 reaction equation
C[N:2]([CH3:17])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.[NH2:18][C:19]1[N:20]=[C:21](C)[NH:22][C:23]=1C#N.[C:27](O)(=O)C>>[CH3:27][C:3]1[CH:4]=[C:5]([C:7]2[CH:8]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:11][CH:12]=2)[N:20]2[CH:21]=[N:22][C:23]([C:19]#[N:18])=[C:17]2[N:2]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 7300243-Dimethylamino-3'-trifluoromethylacrylophenoneHCID 12239848HCID 12239848, compound

Product 1

HCID 23329856HCID 23329856, compound

Procedure

A mixture of 0.01 mole of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 50 ml. of glacial acetic acid and 0.01 mole of 4-amino-2-methyl-5-imidazolecarbonitrile is refluxed for 5 hours. The solvent is removed under reduced pressure and the residue worked up as for Example 29 to give the product of the example.

Workup

  1. customThe solvent is removed under reduced pressure
  2. customto give the product of the example

Sources & evidence

ORD record
ord-b0c9e31365d34a8eb573c7aa79b9239c
Source dataset
uspto-grants-1980_11
Patent number
US04236005

Reaction notes

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