反应详情

温度

0 °C

To a pre-cooled solution (0° C.) of the compound from Step F of Example 2 (28 mg, 0.10 mmol) in DMF (0.5 mL) was added N-bromosuccinimide (0.018 g, 0.10 mmol) in DMF (0.5 mL) dropwise. The solution was stirred at 0° C. for 20 min, then at room temperature for 10 min. The reaction was quenched by addition of methanol (4 mL) and evaporated in vacuo. The crude product was purified on silica gel using methanol/dichloromethane (1:9) as eluent. Fractions containing the product were pooled and evaporated in vacuo to give the desired product (13.0 mg) as a colorless solid.

1. waitat room temperature for 10 min
2. customThe reaction was quenched by addition of methanol (4 mL)
3. customevaporated in vacuo
4. customThe crude product was purified on silica gel
5. additionFractions containing the product
6. customevaporated in vacuo