Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-amino-1H-pyrazole-4,5-dicarbonitrile → 3-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-amino-1H-pyrazole-4,5-dicarbonitrile | HCID 338830 | — |
| 반응물 | Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl ester | HCID 613145 | — |
| 반응물 | 3-Dimethylamino-3'-trifluoromethylacrylophenone | HCID 730024 | — |
| 생성물 | 3-Cyano-7-(alpha,alpha,alpha-trifluoro-m-tolyl)pyrazolo-[1,5-a]pyrimidine-2-carbonitrile | HCID 11370400 | — |
반응 단계
A mixture of 4.86 g. of 3-dimethylamino-3'-(trifluoromethyl)acrylophenone, 50 ml. of glacial acetic and 2.66 g. of 3-aminopyrazole-4,5-dicarbonitrile is refluxed for 10 hours and the solvent removed under reduced pressure. The residue is reacted with trifluoroacetic anhydride to give the product of the example.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04236005 |
| 출처 데이터셋 | uspto-grants-1980_11 |
| ORD ID | ord-8a041eab68fa4b0f9476f8937d90c71f |
| 출처 메모 | uspto-grants-1980_11 |