反应详情

To the crude compound from Step A (2.54 g) in THF (18 mL) was added aqueous 2N LiOH (6 mL). The resulting mixture was stirred at room temperature for 3 h, the THF evaporated in vacuo and the resulting aqueous phase neutralized by addition of aqueous 2N hydrochloric acid. The mixture was adsorbed onto silica gel by evaporation in vacuo and purified on silica gel using methanol/dichloromethane (1:4) as the eluent. Fractions containing the product were combined and evaporated in vacuo to give the desired product as a colorless powder.

1. customthe THF evaporated in vacuo
2. additionthe resulting aqueous phase neutralized by addition of aqueous 2N hydrochloric acid
3. customThe mixture was adsorbed onto silica gel by evaporation in vacuo
4. custompurified on silica gel
5. additionFractions containing the product
6. customevaporated in vacuo