反应详情

A mixture of 0.95 g. of 3-bromo-7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine, 0.45 g. cuprous cyanide and 25 ml. of dimethylformamide is refluxed for 16 hours. Evaporation of the reaction mixture gave a residue which was triturated with methylene chloride. The methylene chloride solution is passed through a short column of hydrous magnesium silicate. The effluent is collected and refluxed on a steam bath with gradual addition of n-hexane and the desired nitrile crystallized from solution, m.p. 141°-143° C.

1. additionA mixture of 0.95 g
2. customEvaporation of the reaction mixture
3. customgave a residue which
4. customwas triturated with methylene chloride
5. customThe effluent is collected
6. temperaturerefluxed on a steam bath with gradual addition of n-hexane
7. customthe desired nitrile crystallized from solution, m.p. 141°-143° C.