反应详情

One gram of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide and 5 ml. of phosphorus oxychloride is refluxed for 3 hours. The reaction mixture is evaporated to dryness and the residue is dissolved in methylene chloride, washed with saturated sodium bicarbonate solution, dried with anhydrous sodium sulfate. After passing through a short pad of hydrous magnesium silicate with eluent methylene chloride. Concentration of the eluent with addition of n-hexane gives the product, m.p. 141°-143° C.

1. customThe reaction mixture is evaporated to dryness
2. dissolutionthe residue is dissolved in methylene chloride
3. washwashed with saturated sodium bicarbonate solution
4. dry with materialdried with anhydrous sodium sulfate
5. additionConcentration of the eluent with addition of n-hexane
6. customgives the product, m.p. 141°-143° C.