反应详情

Methylamine gas was condensed into a sealed tube at −78° C., and a solution of 5-chloro-2-benzofuran-1(3H)-one (6.68 g, 39.8 mmol) in methanol (30 mL) was added. The solution was slowly warmed to room temperature overnight; The reaction was concentrated in vacuo, and the residue was partitioned between water and and chloroform. After three extractions with chloroform, the combined organics were dried over sodium sulfate, filtered, and concentrated in vacuo to afford 4-chloro-2-(hydroxymethyl)-N-methylbenzamide.

1. customcondensed into a sealed tube at −78° C.
2. concentrationThe reaction was concentrated in vacuo
3. customthe residue was partitioned between water and and chloroform
4. extractionAfter three extractions with chloroform
5. dry with materialthe combined organics were dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo