Phosphorus oxychloride → 7-Chloro-5-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine

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Reaction Steps

A mixture of 1.75 g. of 7-hydroxy-5-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine and 15 ml. of phosphorus oxychloride is refluxed for 2 hours. After evaporation at reduced pressure, ice is added to the residue and the desired compound is extracted with methylene chloride. After washing the organic layer with a saturated saline solution and drying with solid anhydrous sodium sulfate, evaporation gives the desired compound, m.p. 137°-139° C.

Provenance & Evidence